Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery

Author(s): Shawn He, George Tourkakis, Oleg Berezin, Nikolay Gerasimchuk, Hairong Zhang, Haiying Zhou, Asaf Izraely, Walter J. Akers and Mikhail Y. Berezin
Date of Publication: June 2016
Abstract:

Temperature-responsive nanoparticles used in conjunction with hyperthermia promise to provide synergistic effects for increasing drug efficacy. We propose a near-infrared (NIR) fluorescent system based on a upper critical solution temperature (UCST) polymer, ISP2, integrated with a NIR fluorescent dye HITC for in vivo tracking. The system forms a nanoparticle that increases its volume as temperature increases, similar to the expansion of a Hoberman sphere. The nanospheres nearly doubled in size, from 80 nm to 140 nm, during a temperature increase from 40 °C to 65 °C.

Citation: He, S., Tourkakis, G., Berezin, O., Gerasimchuk, N., Zhang, H., Zhou, H., Izraely, A., Akers, W. J., & Berezin, M. Y. (2016). Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery. Journal of Materials Chemistry C, 4(14), 3028-3035.
Team(s): Plant Team